• Evolution of the germline mutation rate across vertebrates 

      Bergeron, Lucie A.; Besenbacher, Søren; Zheng, Jiao; Li, Panyi; Bertelsen, Mads Frost; Quintard, Benoit; Hoffman, Joseph I.; Li, Zhipeng; St. Leger, Judy; Shao, Changwei; Stiller, Josefin; Gilbert, Marcus Thomas Pius; Schierup, Mikkel H.; Zhang, Guojie (Peer reviewed; Journal article, 2023)
      The germline mutation rate determines the pace of genome evolution and is an evolving parameter itself1. However, little is known about what determines its evolution, as most studies of mutation rates have focused on single ...
    • The germline mutational process in rhesus macaque and its implications for phylogenetic dating 

      Bergeron, Lucie A.; Besenbacher, Søren; Bakker, Jaco; Zheng, Jiao; Li, Panyi; Pacheco, George; Sinding, Mikkel-Holger S.; Kamilari, Maria; Gilbert, Marcus Thomas Pius; Schiedrup, Mikkel H.; Zhang, Guojie (Peer reviewed; Journal article, 2021)
      Background Understanding the rate and pattern of germline mutations is of fundamental importance for understanding evolutionary processes. Results Here we analyzed 19 parent-offspring trios of rhesus macaques (Macaca ...
    • Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α 

      Langkilde, Ane; Olsen, Lene Christin; Sætrom, Pål; Drabløs, Finn Sverre; Besenbacher, Søren; Raaby, Line; Johansen, Claus; Iversen, Lars (Peer reviewed; Journal article, 2016)
      Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain skin inflammation. ...